Affiliation:
1. Divisions of Parasitology and Process Chemistry Division, Central Drug Research Institute (CSIR), M G Marg, Lucknow-226001, UP, India.
2. Divisions of Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), M G Marg, Lucknow-226001, UP, India
Abstract
Filariasis is caused by thread-like nematode worms, classified according to their presence in the vertebrate host. The cutaneous group includes Onchocerca volvulus, Loa loa and Mansonella streptocerca; the lymphatic group includes Wuchereria bancrofti, Brugia malayi and Brugia timori and the body cavity group includes Mansonella perstans and Mansonella ozzardi. Lymphatic filariasis, a mosquito-borne disease, is one of the most prevalent diseases in tropical and subtropical countries and is accompanied by a number of pathological conditions. In recent years, there has been rapid progress in filariasis research, which has provided new insights into the pathogenesis of filarial disease, diagnosis, chemotherapy, the host–parasite relationship and the genomics of the parasite. Together, these insights are assisting the identification of novel drug targets and the discovery of antifilarial agents and candidate vaccine molecules. This review discusses the antifilarial activity of various chemical entities, the merits and demerits of antifilarial drugs currently in use, their mechanisms of action, in addition to antifilarial drug targets and their validation.
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
23 articles.
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