Issues in the safety testing of metabolites-Reference-Cited by-同舟云学术

Issues in the safety testing of metabolites

Published:2009-11 Issue:8 Volume:1 Page:1381-1390
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Gross Gerhard¹,Wilson Ian¹

Affiliation:

1. Department of Clinical Pharmacology, Drug Metabolism and Pharmacokinetics, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.09.101

Reference45 articles.

1. Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites

2. Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

3. Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

4. Isotopic enrichment enhancement in metabonomic analysis of UPLC–MS data sets

5. Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

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