Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development-Reference-Cited by-同舟云学术

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

Published:2009-01-30 Issue:2 Volume:22 Page:280-293
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Leclercq Laurent¹,Cuyckens Filip¹,Mannens Geert S. J.¹,de Vries Ronald¹,Timmerman Philip¹,Evans David C.¹

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, Global Preclinical Development, Johnson & Johnson Pharmaceutical Research and Development, A Division of Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium, and Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, New Jersey

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx800432c

Reference48 articles.

1. Drug Metabolites in Safety Testing

2. Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

3. SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING

4. Letter to the Editor

5. Metabolites and Safety: What Are the Concerns, and How Should We Address Them?

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