Affiliation:
1. Institut de Chimie Organique et Analytique, Centre National de Recherche Scientifique Unité Mixte de Recherche 6005, Université d’Orléans, 45067 Orléans, France.
Abstract
In recent decades, nucleosides analogs have been the cornerstone in the treatment of various diseases, such as AIDS, herpes and hepatitis. More than 40 modified nucleosides are officially approved by the US FDA and represent the major compound class for inhibition of viral replication. By comparison with traditional conditions, microwave irradiation offers a powerful tool that can increase yields and decrease reaction time, with simple manipulation and an environmentally friendly way. Here, we report the latest progress in nucleoside synthesis using microwave irradiation.
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
8 articles.
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