Affiliation:
1. State Enterprise “L. I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine”, Kyiv, Ukraine
Abstract
Objective: analysis and summary of the literature data and own studies on the possibility of using biomarkers of exposure and effect of organophosphorus compounds (OPCs), determination of immunological biomarkers of the effect under exposure to OPCs that cause delayed neurotoxicity (DN). Materials and Methods. Analytical methods were used in the work: collection of scientific information on the topic, analysis of data and scientific summary of the results. Re-assessment of the effect of OPCs causing DN was performed from the perspective of determination of the most informative immunological biomarkers of the effect of known neurotoxicants. Analysis of the study results of the effect of neurotoxic OPCs, triorthocresyl phosphate (TOCP), Afos on the immune system was performed using the most sensitive model — chicken breed Leghorn in isotoxic doses (500 mg/kg and 200 mg/kg, respectively) using common immunotoxicology methods. Results and Conclusions. The article analyses and concludes current literary data on the justified use of biomarkers of exposure and effect of OPCs that are widespread in the environmental objects and are one of the reasons of acute and chronic poisoning in the population. We’ve reviewed aspects of the necessity for implementation of scientifically justified approach to the development and assessment of biomarkers and creation of the unified diagnostic complex that includes biomarkers of exposure, specific and non-specific action, with wider diagnostic abilities compared with determination of isolated parameters that is the basis for diagnostics, efficient treatment and prediction of consequences of poisoning with OPCs. Based on the results of own studies, we proposed the use of some parameters as the immunological biomarkers of the effect of OPCs with DN: the level of finely dispersed circulating immune complexes in the blood serum and the level of anti-brain antibodies, the number and functional activity of blood neutrophils; the number of T-and B-lymphocytes and their functional activity; the number of NK-cells, T-helper cells, and T-suppressors.
Publisher
L. I. Medved Research Center of Preventive Toxicology, Food and Chemical Safety
Reference48 articles.
1. Luzhnikov E. A. Acute poisoning: Guideline for physician. 2nd edition, revised and enlarged. /E. A. Luzhnikov, L. H. Kostomarova – M.: Meditsina. – 2000. – 434 p.
2. Zhminko P. H. Immune system as a target of toxic action of chemical substances / P. H. Zhminko // Actual topics of transport medicine. – No. 1 (23). – 2011. – P.17 – 30.
3. Zabrodskii P. F. Immunotoxicology of organophosphorus compounds / P. F. Zabrodskii. – Saratov. Publishing house “Saratovskii istochnik”. – 2016. – 289 p.
4. Toxicants with anticholinesterase action: mechanism of action, clinical signs and actual topics of provision with antidotes / L. A. Ustinova, N. M. Seredynska, N. V. Kurdil [et al.] // Current problems of toxicology, food and chemical safety. – 2017. - No. 3 (79) - P. 73-82.
5. Díaz-Resendiz K. J. G. Modulation of Immune Response by Organophosphorus Pesticides: Fishes as a Potential Model in Immunotoxicology / K. J. G. Díaz-Resendiz, G. A. Toledo-Ibarra, M. I. Girón-Pérez // Hindawi Publishing Corporation. Journal of Immunology Research. – V. 2015. – 10 p.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献