Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

Author:

Tang Cheng1ORCID,Herikstad Roger2,Parthasarathy Aishwarya1,Libedinsky Camilo123,Yen Shih-Cheng24ORCID

Affiliation:

1. Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore

2. The N1 Institute for Health, National University of Singapore (NUS), Singapore, Singapore

3. Department of Psychology, NUS, Singapore, Singapore

4. Innovation and Design Programme, Faculty of Engineering, NUS, Singapore, Singapore

Abstract

The lateral prefrontal cortex is involved in the integration of multiple types of information, including working memory and motor preparation. However, it is not known how downstream regions can extract one type of information without interference from the others present in the network. Here, we show that the lateral prefrontal cortex of non-human primates contains two minimally dependent low-dimensional subspaces: one that encodes working memory information, and another that encodes motor preparation information. These subspaces capture all the information about the target in the delay periods, and the information in both subspaces is reduced in error trials. A single population of neurons with mixed selectivity forms both subspaces, but the information is kept largely independent from each other. A bump attractor model with divisive normalization replicates the properties of the neural data. These results provide new insights into neural processing in prefrontal regions.

Funder

Ministry of Education - Singapore

National University of Singapore and National University Health System Strategic Research Award

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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