Building bridges between cellular and molecular structural biology-Reference-Cited by-同舟云学术

Building bridges between cellular and molecular structural biology

Published:2017-07-06 Issue: Volume:6 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Patwardhan Ardan¹^ORCID,Brandt Robert²,Butcher Sarah J³,Collinson Lucy⁴,Gault David⁵,Grünewald Kay⁶,Hecksel Corey⁷,Huiskonen Juha T⁶,Iudin Andrii¹,Jones Martin L⁴^ORCID,Korir Paul K¹,Koster Abraham J⁸,Lagerstedt Ingvar⁹,Lawson Catherine L¹⁰,Mastronarde David¹¹,McCormick Matthew¹²,Parkinson Helen¹³,Rosenthal Peter B¹⁴,Saalfeld Stephan¹⁵^ORCID,Saibil Helen R¹⁶,Sarntivijai Sirarat¹³,Solanes Valero Irene⁹,Subramaniam Sriram¹⁷,Swedlow Jason R¹⁸,Tudose Ilinca¹³,Winn Martyn¹⁹,Kleywegt Gerard J²⁰

Affiliation:

1. Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom

2. Visualization Sciences Group, FEI, Mérignac, France

3. Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Helsinki, Finland

4. Electron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom

5. Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom

6. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

7. National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States

8. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

9. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom

10. Center for Integrative Proteomics Research and the Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Piscataway, United States

11. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, United States

12. Kitware, Inc., Carrboro, United States

13. Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom

14. Structural Biology of Cells and Viruses, Francis Crick Institute, London, United Kingdom

15. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States

16. Institute of Structural and Molecular Biology, Department of Crystallography, Birkbeck College, London, United Kingdom

17. Laboratory for Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States

18. Centre for Gene Regulation and Expression and the Division of Computational Biology, University of Dundee, Dundee, United Kingdom

19. Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot, United Kingdom

20. Molecular and Cellular Structure Cluster, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom

Abstract

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.

Funder

Medical Research Council

European Commission

Wellcome Trust

National Institutes of Health

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/25835/elife-25835-v2.pdf

Reference28 articles.