Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus

Author:

Habig Michael12ORCID,Kema Gert HJ34ORCID,Holtgrewe Stukenbrock Eva12ORCID

Affiliation:

1. Environmental Genomics, Christian-Albrechts University of Kiel, Kiel, Germany

2. Max Planck Institute for Evolutionary Biology, Plön, Germany

3. Wageningen Plant Research, Wageningen University and Research, Wageningen, The Netherlands

4. Laboratory of Phytopathology, Wageningen University and Research, Wageningen, The Netherlands

Abstract

Meiosis is a key cellular process of sexual reproduction that includes pairing of homologous sequences. In many species however, meiosis can also involve the segregation of supernumerary chromosomes, which can lack a homolog. How these unpaired chromosomes undergo meiosis is largely unknown. In this study we investigated chromosome segregation during meiosis in the haploid fungus Zymoseptoria tritici that possesses a large complement of supernumerary chromosomes. We used isogenic whole chromosome deletion strains to compare meiotic transmission of chromosomes when paired and unpaired. Unpaired chromosomes inherited from the male parent as well as paired supernumerary chromosomes in general showed Mendelian inheritance. In contrast, unpaired chromosomes inherited from the female parent showed non-Mendelian inheritance but were amplified and transmitted to all meiotic products. We concluded that the supernumerary chromosomes of Z. tritici show a meiotic drive and propose an additional feedback mechanism during meiosis, which initiates amplification of unpaired female-inherited chromosomes.

Funder

State of Schleswig Holstein

Max-Planck-Gesellschaft

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference61 articles.

1. Spindle asymmetry drives non-Mendelian chromosome segregation;Akera;Science,2017

2. Trimmomatic: a flexible trimmer for Illumina sequence data;Bolger;Bioinformatics,2014

3. Somatic pairing of homologs in budding yeast: existence and modulation;Burgess;Genes & Development,1999

4. Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p;Cha;Genes & Development,2000

Cited by 28 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3