Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

Author:

Yokouchi Mariko12,Atsugi Toru13,Logtestijn Mark van4,Tanaka Reiko J4ORCID,Kajimura Mayumi56ORCID,Suematsu Makoto56ORCID,Furuse Mikio78ORCID,Amagai Masayuki19ORCID,Kubo Akiharu1ORCID

Affiliation:

1. Department of Dermatology, Keio University School of Medicine, Tokyo, Japan

2. Nerima General Hospital, Tokyo, Japan

3. KOSÉ Corporation, Tokyo, Japan

4. Department of Bioengineering, Faculty of Engineering, Imperial College London, London, United Kingdom

5. Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan

6. Suematsu Gas Biology Project, Exploratory Research for Advanced Technology, Japan Science and Technology, Tokyo, Japan

7. Division of Cell Structure, National Institute for Physiological Sciences, Okazaki, Japan

8. Department of Physiological Sciences, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Japan

9. RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Abstract

In multicellular organisms, cells adopt various shapes, from flattened sheets of endothelium to dendritic neurons, that allow the cells to function effectively. Here, we elucidated the unique shape of cells in the cornified stratified epithelia of the mammalian epidermis that allows them to achieve homeostasis of the tight junction (TJ) barrier. Using intimate in vivo 3D imaging, we found that the basic shape of TJ-bearing cells is a flattened Kelvin's tetrakaidecahedron (f-TKD), an optimal shape for filling space. In vivo live imaging further elucidated the dynamic replacement of TJs on the edges of f-TKD cells that enables the TJ-bearing cells to translocate across the TJ barrier. We propose a spatiotemporal orchestration model of f-TKD cell turnover, where in the classic context of 'form follows function', cell shape provides a fundamental basis for the barrier homeostasis and physical strength of cornified stratified epithelia.

Funder

Ministry of Health, Labour and Welfare

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science, and Technology

Lydia O'Leary Memorial Pias Dermatological Foundation

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Maruho Co., Ltd

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference44 articles.

1. ABCA12 mutations and autosomal recessive congenital ichthyosis: a review of genotype/phenotype correlations and of pathogenetic concepts;Akiyama;Human Mutation,2010

2. Significance of cell shape in tissue architecture;Allen;Nature,1976

3. Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1;Amagai;Nature Medicine,2000

4. Characterization of the human involucrin promoter using a transient beta-galactosidase assay;Carroll;Journal of Cell Science,1992

Cited by 85 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3