Affiliation:
1. Department of Pharmacy, Oriental University, Indore, Madhya Pradesh – 453555.
Abstract
Cancer can conquer or feast on nearly all portions of the body. The cumulative illness and high humanity of cancer generate an innumerable claims for the expansion of innovative anticancer drugs. Coumarin (known as 1,2-benzopyrone or o-hydroxycinnamic acid-8-lactone) encompasses a huge class of phenolic offshoots that originate in plants and they are entailed of bonded benzene and a-pyrone rings. Numerous studies have exposed that several substituents on the coumarin essential structure stimulus different biological activities. Coumarin advert a character of pathways in cancer like kinase inhibition, cell cycle annexation, angiogenesis inhibition, telomerase inhibition, antimitotic activity, carbonic anhydrase inhibition, monocarboxylate transporters inhibition, aromatase inhibition, and sulfatase inhibition. Coumarin moiety is a beneficial template for the progress of novel anticancer agents.
Reference71 articles.
1. Chia-Hsiung C, Ku-Chung L, Wai-Theng W, Yen-Fang X, Lin. C. Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin derivative, DMAC, in human colon cancer cells. Chem. Bio. Int. 2014; 218:42-49.
2. Saidu N, Valente S, Emilie B, Gilbert K, Denyse B, Mathias M. Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells. Biog. Med. Chem. 2012; 4:1584-1593.
3. Anees A, Pangal, JA, Shaikh Ejazuddin MK. Current Developments of C3-Substituted Coumarin Hybrids as Anti-Cancer Agents. Int. J. Pharm. Sci. Rev. Res. 2017; 42(1):161-168.
4. Jain PK, Himanshu J. Coumarin: Chemical and Pharmacological Profile. Journal of Applied Pharmaceutical Science, 2012; 2(6):236-240.
5. Douglas H, Gabriele B, Emily B. Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest. 2000; 105(8):1045–1047.
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