In-vitro studies based on Natural compounds with Antitumor properties used for Ameliorating/ Preventing Cancer-Reference-Cited by-同舟云学术

In-vitro studies based on Natural compounds with Antitumor properties used for Ameliorating/ Preventing Cancer

Published:2023-11-28 Issue: Volume: Page:443-447
ISSN:0974-4150
Container-title:Asian Journal of Research in Chemistry
language:en
Short-container-title:AJRC

Author:

Singh Akanksha¹,Kumari Priyanka¹,Sharma Divya¹,Singh Arjun²

Affiliation:

1. Department of Pharmacognosy, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.

2. Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.

Abstract

Despite recent advances in the field of chemically synthesized pharmaceutical agents, nature remains the primary source of bioactive molecules. Natural product research is a valuable approach for the discovery and development of novel biologically active compounds with unique structures and mechanisms of action. Despite their use in traditional treatment regimes, plant-derived compounds still account for a significant portion of today's pharmaceutical agents. Their medical significance is widely acknowledged in the field of oncology, particularly as an alternative to the limitations of conventional chemotherapy (severe side effects and inefficacy due to the occurrence of multi-drug resistance). Furthermore, the preclinical to clinical evaluation of the most recently studied natural compounds with potent antitumor activity (e.g., resveratrol, curcumin, betulinic acid, etc.) in terms of anticancer mechanisms of action and potential indications as chemotherapeutic or chemopreventive agents and sensitizers is depicted. Finally, this review describes several effective platforms for the encapsulation and targeted delivery of natural compounds in cancer treatment. This review uses representation to provide a comprehensive view of the mechanism of action of the agents of natural origin.

Publisher

A and V Publications

Reference34 articles.

1. Gautam, Yashveer, Sonam Dwivedi, Ankita Srivastava, Hamidullah, Arjun Singh, D. Chanda, Jyotsna Singh, Smita Rai, RiturajKonwar, and Arvind S. Negi. 2-(3′,4′-Dimethoxybenzylidene)Tetralone Induces Anti-Breast Cancer Activity through Microtubule Stabilization and Activation of Reactive Oxygen Species. RSC Advances. 2016; 6(40): 33369–79. https://doi.org/10.1039/C6RA02663J.

2. Hamid, A.A., Mohammad Hasanain, Arjun Singh, Balakishan Bhukya, Omprakash, Prema G. Vasudev, Jayanta Sarkar, et al. Synthesis of Novel Anticancer Agents through Opening of Spiroacetal Ring of Diosgenin. Steroids. 2014; 87: 108–18. https://doi.org/10.1016/j.steroids.2014.05.025.

3. Hamid, A.A., Tanu Kaushal, Raghib Ashraf, Arjun Singh, Amit Chand Gupta, Om Prakash, Jayanta Sarkar, et al. (22β,25R)-3β-Hydroxy-Spirost-5-En-7-Iminoxy-Heptanoic Acid Exhibits Anti-Prostate Cancer Activity through Caspase Pathway. Steroids. 2017; 119: 43–52. https://doi.org/10.1016/j.steroids.2017.01.001.

4. Jain, Shilpi, Arjun Singh, Puja Khare, D. Chanda, Disha Mishra, Karuna Shanker, and Tanmoy Karak. Toxicity Assessment of Bacopa Monnieri L. Grown in Biochar Amended Extremely Acidic Coal Mine Spoils. Ecological Engineering. 2017; 108: 211–19. https://doi.org/10.1016/j.ecoleng.2017.08.039.

5. Khwaja, Sadiya, Kaneez Fatima, Mohammad Hasanain, Chittaranjan Behera, Avneet Kour, Arjun Singh, Suaib Luqman, et al. Antiproliferative Efficacy of Curcumin Mimics through Microtubule Destabilization. European Journal of Medicinal Chemistry. 2018; 151: 51–61. https://doi.org/10.1016/j.ejmech.2018.03.063.