Implementation of Hydrotropic Solvents for UV Spectrophotometric Assessment of Esomeprazole-Loaded Microspheres: Greenness Evaluation

Abstract

Background: The present framework is built on top of a basic UV-spectrophotometric method that was created and proven to be effective for measuring different dose forms and bulk esomeprazole. Numerous hydrotropic reagents were tried to improve the solubility of ESM to enhance the same. Materials and Methods: Esomeprazole has the highest absorbance at 299nm in 1MUrea solvent for a stock solution and subsequent dilutions. The ICH recommendations were used to determine a number of analytical parameters. Results: Precision it is the degree of repeatability (with the same conditions) or reproducibility (with the different conditions) of method; the% RSD for repeatability was 0.470, and (r2) was 0.998. The Accuracy was found to be for 50% was 101.7%, 100% was 100.1%, and 150% was 99.79% for esomeprazole. The linearity concentration of range was 2-10µg/ml. Discussion: Analytical Greenness compares different parameters and different steps of the analytical process and the AGREE report was found to be 0.64. Recovery studies corroborated and statistically validated the analysis's conclusions.