Affiliation:
1. Department of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar - 562159 Karnataka, India.
Abstract
A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Remogliflozin Etabonate in pure drug and tablet dosage form. The absorbance was measured at 239.8nm using Ethanol as solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.997. Limit of detection (LOD) was found to be 1.220µg/ml and Limit of quantitation (LOQ) was found to be 5.220µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.
Reference20 articles.
1. Statement on a nonproprietory name adopted by the USAN council
2. "Avolynt Announces Completion of Phase 2b BRID Study of SGLT2 Inhibitor Remogliflozin-Etabonate" (Press release). Avolynt, Inc. Retrieved July 24, 2018.
3. S Mudaliar, AD Armstrong, AA Mavian, R Semmes Connor O, KP Mydlow, J Ye, et al. (November 2012). "Remogliflozin Etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type I diabetes". Diabetes Care. 35 (11): 2198–200. doi:10.2337/dc12-0508. PMC 3476920.PMID 23011728.
4. RL Dobbins, R Semmes Connor O, A Kapur, C Kapitza, G Golor, I Mikoshiba, et al. (January 2012). "Remogliflozin Etabonate, a selective inhibitor of the sodium-dependent transporter II reduces serum glucose in typeII diabetes mellitus patients". Diabetes, Obesity and Metabolism. 14 (1): 15–22. doi:10.1111/j.1463-1326.2011.01462.x. PMID 21733056.S2CID 23372554.
5. PA Sykes, R Semmes Connor O, R Dobbins, JD Dorey, DJ Lorimer, S Walker, et al. (January 2015). "Randomized trial showing efficacy and safety of twice-daily Remogliflozin Etabonate for the treatment of type II diabetes". Diabetes, Obesity and Metabolism. 17 (1): 94–7. doi:10.1111/dom.12391. PMID 25223369.S2CID 6436562.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献