A Brief Review on Liquid Chromatography-Mass Spectrometry/LCMS and its Application

Author:

Kumar J. Vyas Amit1,B. Mishra Sonali1,Patel A. B.1,Patel N. K.2,Shah S. R.2,Sheth D. B.2

Affiliation:

1. B. K. Mody Government Pharmacy College, Rajkot, Gujrat (India).

2. L. M. College of Pharmacy, Ahmedabad, Gujarat (India).

Abstract

Liquid Chromatography- Mass Spectrometry is a powerful analytical technique having high Sensitivity and Specificity. LC-MS combines the separation capabilities of Liquid Chromatography with the mass analysis capabilities of Mass Spectrometry. Liquid Chromatography separates the mixture, which is having multiple components, and then Mass Spectrometry provides the Spectral information which is used to identify each separated component. Interfaces are used in LC-MS system to transfer the maximum amount of analyte, remove a significant portion of the mobile phase, and preserves the chemical identity. Different types of Interfaces are used which include Atmospheric-Pressure Ionization, Electrospray Ionization, Atmospheric Pressure Chemical Ionization, Thermospray and Plasma Spray Ionization, Particle Beam Ionization, Continuous Flow Fast Atom Bombardment. LC-MS having a wide range of application in various field which include Pharmaceutical, Drug Development, Forensic Science, Cosmetic, Petrochemistry, Environment, Food Analysis, Biochemical Application. In this article Principle, Instrument and Application are discussed briefly.

Publisher

A and V Publications

Reference98 articles.

1. Beckett AH and Stenlake GH. Practical Pharmaceutical Chemistry. fourth ed., CBS Publishers and distributors, New Delhi. 2005.

2. Sharma BK. Instrumental methods of chemical analysis, twenty third ed., Goel Publishing House, Meerut,

3. Kumar PR, Dinesh SR, and Rini R. LCMS- A Review and a Recent Update. World Journal of Pharmacy and Pharmaceutical Science. 2016, 378.

4. Sethi PD. High Performance Liquid Chromatography, Quantitative analysis of Pharmaceutical Formulation. CBS Publication, New Delhi,2001

5. Bhole RP et al. Zambare YB. Liquid Chromatography-Mass Spectrometry Technique-A Review. Research Journal of Pharmacy and Technology. 2020;13(1):505-16.

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3