Affiliation:
1. B. K. Mody Government Pharmacy College, Rajkot, Gujrat (India).
2. L. M. College of Pharmacy, Ahmedabad, Gujarat (India).
Abstract
Liquid Chromatography- Mass Spectrometry is a powerful analytical technique having high Sensitivity and Specificity. LC-MS combines the separation capabilities of Liquid Chromatography with the mass analysis capabilities of Mass Spectrometry. Liquid Chromatography separates the mixture, which is having multiple components, and then Mass Spectrometry provides the Spectral information which is used to identify each separated component. Interfaces are used in LC-MS system to transfer the maximum amount of analyte, remove a significant portion of the mobile phase, and preserves the chemical identity. Different types of Interfaces are used which include Atmospheric-Pressure Ionization, Electrospray Ionization, Atmospheric Pressure Chemical Ionization, Thermospray and Plasma Spray Ionization, Particle Beam Ionization, Continuous Flow Fast Atom Bombardment. LC-MS having a wide range of application in various field which include Pharmaceutical, Drug Development, Forensic Science, Cosmetic, Petrochemistry, Environment, Food Analysis, Biochemical Application. In this article Principle, Instrument and Application are discussed briefly.
Reference98 articles.
1. Beckett AH and Stenlake GH. Practical Pharmaceutical Chemistry. fourth ed., CBS Publishers and distributors, New Delhi. 2005.
2. Sharma BK. Instrumental methods of chemical analysis, twenty third ed., Goel Publishing House, Meerut,
3. Kumar PR, Dinesh SR, and Rini R. LCMS- A Review and a Recent Update. World Journal of Pharmacy and Pharmaceutical Science. 2016, 378.
4. Sethi PD. High Performance Liquid Chromatography, Quantitative analysis of Pharmaceutical Formulation. CBS Publication, New Delhi,2001
5. Bhole RP et al. Zambare YB. Liquid Chromatography-Mass Spectrometry Technique-A Review. Research Journal of Pharmacy and Technology. 2020;13(1):505-16.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献