An Overview of Analytical and Bioanalytical Techniques for the determination of Tyrosine Kinase Inhibitors

Author:

Gowthami M.1,R Rajesh1

Affiliation:

1. Department of Pharmaceutical Analysis, Acharya & BM Reddy College of Pharmacy, Soladevanahalli, Hessarghatta Main Road, Bengaluru, Karnataka, India.

Abstract

Tyrosine KIs have become a targeted drug therapy for different malignancies. Over the past ten years, kinase inhibitors, including monoclonal antibodies and small-molecule TKIs targeted at kinases, have become a significant class of chemotherapeutic agents. A number of studies documenting the design, usage and validation of bioanalytical methods for TCKIs have been published as a result of the rising need for bioanalytical approaches to both qualitatively and quantitatively study such compounds. Many biomatrices, including blood, cerebrospinal fluid, urine, tissue, and even liver microsomes, can be used to quantify TCKIs. The majority of papers explain the technological framework of analytical methods that can do this. In recent times, there has also been an increase in interest in the discovery of intermediates and biotransformation mechanisms for novel TCKIs. We give a summary of TCKI bioanalytical techniques.

Publisher

A and V Publications

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3