Hepatocellular Carcinoma: A Review

Abstract

Hepatocellular Carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Several risk factors responsible for development of HCC are liver and biliary Cirrhosis, Alcohol consumption, Hepatitis B and C infection, exposure to carcinogenic substance like Aflatoxin and Arsenic, comorbid condition like Obesity and Diabetes etc. In this review we discus about risk factors, screening methods and stages of HCC. Multiple treatment availability such as Radiation therapy, Chemotherapy and Surgical procedures along with newer modalities like Targeted Drug Delivery System, use of nano technology, newer Immunomodulators and Radiofrequency Ablation. Continued improvement in both surgical and nonsurgical approaches has demonstrated significant benefits in overall survival.