Formulation and In vitro Characterization of Linalool and Curcumin CO-Loaded Microparticulate System for Hepatocellular Carcinoma

Abstract

In the entire world, hepatocellular carcinoma (HCC) is the second leading cause of cancer death and the fifth prevalent kind of cancer. For hepatocellular carcinoma, herbal microsphere formulations may be more beneficial than conventional formulations due to their improved component solubility, increased bioavailability, and lower dosage, ability to maintain a therapeutic dose over time, improved stability, and protection against chemical and physical degradation. Combining curcumin with linalool formulations might have a synergistic impact.This preliminary research work is proposed for the formulation and characterization of a linalool and curcumin-co-loaded microparticulate system for hepatocellular carcinoma. The characterization of linalool and curcumin as pure drugs was done by UV spectroscopy and FTIR. The microspheres containing curcumin and linalool were characterized in terms of drug release, entrapment efficiency, zeta potential, particle size, and photomicroscopy and FTIR. Model-fitting curves, including the zero-order, first-order, Korsmeyer-Peppas, Higuchi, and Hixson-Crowell models, were used to study the mechanism of drug release. Out of all the formulations, Formulation F2 was accepted. Good drug release and trapping efficiency were found in Formulation F2. Drug release was found to be at its highest when linalool and chitosan concentrations rose, as was the scenario with release also.