Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique

Abstract

Crystallo-co-agglomeration (CCA) is an innovative technique developed with the intention to produce the drugs with good micromeritic and mechanical characteristics. Yohimbine Hydrochlorideis an anti-retroviral drug with poor dissolution and poor flow properties. Hence the aim of the study is to prepare the crystallo co-agglomerates of Yohimbine Hydrochloridewhich may improve the properties of Yohimbine Hydrochloride.The present study was carried out in order to develop pharmaceutically equivalent, stable, and quality improved agglomerates of Yohimbine Hydrochloridewith enhanced solubility wettability, dissolution rate, flow properties and mechanical properties using hydrophilic polymers and to characterize the physico-chemical properties of prepared crystallo-co-agglomeration.The present work was carried out using PVA and PEG 6000 as the polymers in different ratios by crystallo-co agglomeration method. The various evaluations of prepared agglomerates like micromeritics of the agglomerates such as flowability, packability and compatibility were dramatically improved. The dissolution and disintegration rate of agglomerate was increased in presence of PEG 6000 than compared with PVA.TheYohimbine Hydrochloridepolymer agglomerates were successfully prepared by crystallo-co-agglomeration technique and it was concluded that crystallo-co-agglomeration technique can be successfully employed as an alternative to conventional wet agglomeration.