Formulation and Evaluation of Tinidazole Microgel for Skin Delivery

Abstract

The objective of the present study was to formulate and optimize tinidazolemicrogel. To achieve these objective fourteen formulations of microgel were prepared by emulsion solvent evaporation method using Eudragit polymer. A 32 factorial design was employed in formulating the microgel with concentration of surfactant (A) and stirring speed (B) as independent variables. Percent drug release was considered as dependent variable. The effect of drug-polymer concentration, surfactant concentration, cross-linking agent and stirring speed were evaluated with respect to entrapment efSficiency, particle size, surface characteristics, micromeritic properties, DSC study and in vitro drug release studies. The particle size and entrapment efficiency were found to be varied by changing various formulation parameters like surfactant concentration and stirring speed etc. IR study confirmed the drug-polymer compatibility and scanning electron microscopy indicates that the microgel have the rough and porous surface due to arising as a trace of solvent evaporation during the process. The release profile of tinidazole from Eudragitmicrogel was pH dependent. In acidic medium, the release rate was much slower; however, the drug was released quickly at pH 7.4. It is concluded from the present investigation that Eudragitmicrogel are promising as a carrier for targeted delivery of tinidazole.