Phytochemical screening and Antioxidant activity of Lombok island local Moringa leaf powder (Moringa oleifera) predicted for Diabetes Therapy

Abstract

Moringa (Moringa oleifera) is a plant that easily to find and can grow in lowlands and highlands such as Lombok island relatively inexpensive , and can thrive in almost all parts of Indonesia, such as Lombok island, West Nusa Tenggara province. All parts of this plant can be used as food and traditional medication such as diabetes mellitus. This study aims at identifying the chemical compounds that contained in Moringa oleifera of Lombok island and predicting its role as a treatment of diabetes mellitus disease. Identification of chemical compounds by using the spectropotometry method and antioxidant activity with the DPPH method, the prediction of the potential of Moringa leaves (Moringa oleifera) for Treatment of Diabetes Mellitus with the in Silico approach. Analysis of Pa (probability to be active) by using the approach of Pass Server, predicted that moringa oleifera can be used for the treatment of diabetes. The qualitative analysis results of phytochemical, moringa leaf powder from Lombok Island positive contain of alkaloids, flavonoids, tannins and phenols, and quantitative analysis, moringa leaf powder contain of polyphenols (864.09mgGAE/100g), flavonoids (649.97 mgQE/100g), tannin (306,10mgTAE/100g), quercetin (30.33mgQE/100g), and has an antioxidant capacity (1247.02 mgGAEAC/L) and antioxidant activity with the value IC50 (1312.99 ppm). Moringa leaf powder from Lombok Island contains of alkaloid compounds, polyphenols, flavonoids, tannins, phenols and quercetin and has very weak antioxidant capacity and activity. Moringa leaves (Moringa oleifera) can target RBP4, SLC16A1, SRC and IRS1 protein associated with insulin pathway so that it is predicted to be used for treatment of diabetes mellitus disease.