Amelioration of Cisplatin and Gentamicin Induced Kidney Damage by Caryota urens and Hyophorbe lagenicaulis

Abstract

Background: Nutraceutical potentiality of the plants on the basis of their efficacy and huge phytochemicals present in the aerial parts of Caryota urens(flowers) and Hyophorbe lagenicaulis(leaves) were taken as the background of the study. Aim: The present study investigated the nutraceutical activity and nephroprotective potentiality of Caryota urens flowers and Hyophorbe lagenicaulis leaves against cisplatin and gentamycin induced nephrotoxicity were performed. Materials and Methods: The extract of Caryota urens flowers and Hyophorbe lagenicaulis leaves were screened for preliminary phytochemical analysis,in vitro antioxidant activity andin vivo acute toxicity test was also performed by following OECD guideline 420. In vivo screening for cisplatin and gentamycin induced nephrotoxicity preclinically were also done. Result: It was found that CUFE and HLLE (1:1) suspension administered orally to the albino Wistar rats, no major side effects were seen in any of the experimental animal. The findings obtained from the experimental data were showed that the effect of CUFE and HLLE as potent nutraceuticals in cisplatin and gentamycin induced nephrotoxicity was significant (**p<0.001). Conclusion: These findings concluded that the CUFE and HLLE (1:1) have potent bioactive phyto-pharmaceuticals and natural source of antioxidants present with them. Both the plants have nutritionally rich source of dietary food supplements and due to this they are also helpful in successfully managing commercial drugs induced nephrotoxicity.