Assessment of Anti-urolithic effect of the Ocimum basilicum L. seed extract on Ethylene Glycolinduced urolithiasis in male rats

Abstract

This research aimed to assess the effect of Ocimum basilicum L. seed extract on the urolithiasis. Rats were treated with Cystone (750mg/kg) and hydro-alcoholic extracts in 250 and 500mg/kg doses for 28days. On Day 29, Ethylene glycol induced urolithiasis was verified by evaluating urinary parameters, biochemical parameters, oxidative stress parameters and histology of kidneys. Extract treatment attenuated the urinary parameter elevation and biochemical serum parameters induced by the evidence. Extract treatment also reversed induced changes in urine volume, pH and Magnesium and creatinine clearance, oxidative and histological damage to the EG-caused kidneys. The histology of treated group showed small and low deposits of calculi in the kidney. Extract showed potential calcium oxalate crystal formation, diuretic, antioxidant activity and preserving the balance between stone promoters and inhibitors. This validated study rationalized its medicinal use in urolithiasis.