Histological Evaluation of Uterus and Bone response to Hormonal Contraceptive in Rats

Abstract

Background: Sex hormones play an important role in uterus and bone tissue integration. Oral hormonal contraceptive pills (OCPs) were developed over 50 years ago. Aims of the study: to clarify the histological evaluation of different types of hormonal contraceptive effects on uterus, cervix, ovary, endometrium, and bone in the female albino rat. Materials and methods: The study was conducted on thirty albino rats. three groups each group 10 rats one of them considered as a control group and the other two groups considered as a treated group which taking oral hormonal contraceptive once daily for about 8 weeks and another group takes injectable hormonal contraceptive once weekly for about 8 weeks then euthanized for histological examination. Result: After 8 weeks of drug administration histological findings show significant differences in the thickness of articular cartilage, the thickness of metaphyseal plate, the thickness of trabecular bone, and thickness of endometrium between the control group and experimental group. Conclusion: The current study showed that hormonal contraceptives exhibited histological changes on the uterus and bone which can be correlated to different clinical findings.