A Flavonoid compound of Turbinaria decurrens Bory with The Potential Antioxidant and Anticancer Activity-Reference-Cited by-同舟云学术

A Flavonoid compound of Turbinaria decurrens Bory with The Potential Antioxidant and Anticancer Activity

Published:2021-12-28 Issue: Volume: Page:6207-6210
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Jumaetri Sami Fitriyanti¹,Hariani Soekamto Nunuk¹,Okino Tatsufumi²,Firdaus Firdaus¹,latip Jalifah³

Affiliation:

1. Department of Chemistry, Hasanuddin University, Indonesia.

2. Faculty of Environmental Earth Science, Hokkaido University, Japan.

3. School of Chemical Sciences and Food Technology, Universiti Kebangsaan Malaysia, Selangor.

Abstract

Isolation and characterization of quercetin flavonoid compound from Dutungan Island, South Sulawesi Province, Indonesia has been successfully done from ethyl acetate extract. Extraction method used maceration, isolation used chromatography, anticancer activity with MTT method and antioxidant test used DPPH radical. Structure was discussed with the FT-IR, NMR spectrophotometer and compared with the literature. Total flavonoids from ethyl acetate extract were 4.8 mgEQ/g, IC50 value of antioxidant activity was 4.23 μg/ml using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), and anticancer activity of H460 cells IC50 value was 10.95 μg/ml. The quercetin compound is potential as an anticancer and was first report in the T. decurrens Bory species.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference19 articles.

1. Sami, F. J., Soekamto, N. H., Firdaus, F. and Latip, J. UJI Aktivitas Antioksidan Beberapa Ekstrak Alga Coklat Sargassum polycystum Dan Turbinaria deccurens Asal Pulau Dutungan Sulawesi Selatan Terhadap Radikal DPPH. J. Kim. Ris. 2019; 4(1): 1-6.

2. Rahelivao, M. P., Gruner, M., Andriamanantoanina, H., Bauer, I. and Knölker, H. J. Brown Algae (Phaeophyceae) from the Coast of Madagascar: preliminary Bioactivity Studies and Isolation of Natural Products. Nat. Products Bioprospect. 2015; 5(5): 223-35.

3. Kumar, S. S., Kumar, Y., Khan, M. S. Y. and Gupta, V. New antifungal steroids from Turbinaria conoides (J. Agardh) Kutzing. Nat. Prod. Res. 2010; 24(15): 1481-7.

4. Le Lann, K. et al. Isolation of turbinaric acid as a chemomarker of Turbinaria conoides (J. Agardh) Kützing from South Pacific Islands. J. Phycol. 2014; 50(6): 1048-57.

5. Dhanraj, V., Manivasagam, T. and Karuppaiah, J. Myricetin Isolated from Turbinaria ornata ameliorates rotenone induced parkinsonism in drosophila melanogaster. Int. J. Pharm. Pharm. Sci. 2017; 9(11): 39-44.