Schiff bases compounds prepared from Phenyl hydrazine as a starting material were Synthesized, Characterized, and their Biological activity was Investigated-Reference-Cited by-同舟云学术

Schiff bases compounds prepared from Phenyl hydrazine as a starting material were Synthesized, Characterized, and their Biological activity was Investigated

Published:2022-08-30 Issue: Volume: Page:3595-3598
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Salman Salih Nuha¹,Ibrahem Yahya Widad¹,Yousif Al-Labban Hutham Mahmood¹,Jaloob Aljanaby Ahmed Abduljabbar²

Affiliation:

1. University of Kufa, Faculty of Science, Department of Chemistry, Iraq.

2. University of Kufa, Faculty of Science, Department of Biology, Iraq.

Abstract

Preparation of Schiff bases compounds (A, B, and C) in absolute ethanol using concentrated phenyl hydrazine and various aromatic aldehydes such as (4-chlrobenzaldehyde aldehyde, 4-bromobenzaldehyde, N, N-dimethyl amino benzaldehyde). Melting point, FT, has been used to classify these compounds (A, B, and C). The reactions phases and series were studied using IR spectroscopy and thin layer chromatography (TLC) (ethyl acetate: toluene, 1:4). Three derivate compounds were used as antibacterial activity in this study. The results proved that all derivative compounds provided good inhibition zone against Staphylococcus aureus and pseudomonas aeruginosa especially in concentration 300mg/ml of derivative compound C with diameter inhibition zone 21.433±0.676 and 625.33±0.796 respectively.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference28 articles.

1. Park JK, Chung YM, Kim BG, Yoo YA, Yang BS, Kim JS, Do Yoo Y. N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells. Molecular Cancer Therapeutics. 2004;3(4):403-7.

2. Lattová E, Skřičková J, Zdráhal Z. Applicability of phenylhydrazine labeling for structural studies of fucosylated N-glycans. Analytical Chemistry. 2019;91(13):7985-90. https://doi.org/10.1021/acs.analchem.9b01321

3. Lattová E, Perreault H. Method for investigation of oligosaccharides using phenylhydrazine derivatization. Glycomics. 2009:65-77. https://doi.org/10.1007/978-1-59745-022-5_5

4. Turhan O, Tezbaşaran E. In situ observation of ninhydrin and phenylhydrazine reaction in solution by FTIR. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2013;113:297-301. https://doi.org/10.1016/j.saa.2013.05.002

5. Arduini A, Stern A. Spectrin degradation in intact red blood cells by phenylhydrazine. Biochemical Pharmacology. 1985 Dec 15;34(24):4283-9. https://doi.org/10.1016/0006-2952(85)90286-2

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