<i>N</i>′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells-Reference-Cited by-同舟云学术

N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

Published:2004-04-01 Issue:4 Volume:3 Page:403-407
ISSN:1535-7163
Container-title:Molecular Cancer Therapeutics
language:en
Short-container-title:

Author:

Park Jong Kuk¹,Chung Young Min¹,Kim Byung-Gyu²,Yoo Young-A¹³,Yang Beom-Seok⁴,Kim Jun Suk¹⁵,Yoo Young Do⁶

Affiliation:

1. 1Brain Korea 21 Biomedical Sciences,

2. 5Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute/NIH, Bethesda, MD; and

3. 4Graduate School of Biotechnology, Korea University, Seoul, Korea;

4. 6Life Science Division, Korea Institute of Science and Technology, Seoul, Korea

5. 2Department of Internal Medicine, and

6. 3Genomic Research Center, Korea University Cancer Institute, College of Medicine and

Abstract

Abstract To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/mct/article-pdf/3/4/403/1868060/403-407.pdf

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