MODERN APPROACHES TO ASSESSMENT OF METABOLISM DISORDERS OF XENOBIOTICS DURING THEIR ADMINISTRATION INTO BODY FROM EXTERNAL ENVIRONMENT

Abstract

In this review, there have been considered current approaches to identification and use of indicators that reflected xenobiotics metabolism disorders caused by, on the one hand, by genetically determined biochemical individuality and increased sensitivity of human body, on the other hand - by accumulation of them in body biological fluids during constant administration from external environment. The study of the basic components of enzyme systems that implement metabolism of xenobiotics, can detect abnormalities in the process of detoxification of chemicals, which makes it possible to adjust the main elements of the metabolic transformation of toxicants, and enzymatic detoxification system components considered as markers of metabolism of xenobiotics, due to increased individual sensitivity and stable flow of xenobiotics into the body from the environment.