Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis

Author:

Alymenko M. A.1,Valiev R. Sh.2,Polonikov A. V.3,Golubeva T. N.4,Vasilevskaya A. P.4,Miroshnik E. V.5

Affiliation:

1. Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education; Kursk Regional Health Committee

2. Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education

3. Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University

4. Regional Clinical TB Dispensary

5. Kursk Regional Health Committee

Abstract

The objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculosis.Subjects and Methods. Within the framework of this study, a population sample of unrelated 1081 individuals of Slavic nationalities (mainly Russians) living in the territory of Kursk Oblast was used.Results. The del/del (D/D) GSTM1 genotype was associated with an increased risk of developing tuberculosis, while carrying the del/del (D/D) GSTT1 genotype was associated with a lower risk of developing the disease. Polymorphism 3435T>C ABCB1 (TC genotype) was associated with increased susceptibility to pulmonary tuberculosis in the codominization model, while TT+TC genotypes had the same association in the dominance model.

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

Reference12 articles.

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4. Zemlyakova M.A., Koldibekova Yu.V. Modern approaches to the assessment of metabolic disorders of xenobiotics when they enter the host from the external environment. Ekologiya Cheloveka, 2012, vol. 8, pp. 8-13. (In Russ.)

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