Determination of the macro- and microelement composition of the saliva of СHPP workers

Abstract

BACKGROUND: Chemical homeostasis is a necessary component for maintaining health, and an excessive or insufficient level of macro and microelements in the body is considered a risk factor for the development of pathological changes. AIM: To determine the micro and macro-element composition of the saliva of СHPP workers by capillary electrophoresis. MATERIALS AND METHODS: We used the saliva samples from Omsk СHPP personnel aged 2545 years (main group; n=104) and healthy volunteers aged 2345 years who were not related to the СHРP company (control group; n=195). Capillary electrophoresis was used to evaluate the potassium, sodium, magnesium, calcium, lithium, strontium, barium, and manganese content of all samples. RESULTS: It has been established that potassium, sodium, magnesium, and calcium ions were present in all the samples investigated; however, their balance is considerably disrupted under conditions of technogenic pollution. It was observed that lithium, barium, strontium, and manganese were identified in a greater number of saliva samples from СHPP workers compared to the control group. Strontium was not identified in the saliva of volunteers in the control group; its appearance correlated with working conditions. CONCLUSION: The proposed method allows estimating the degree of technogenic load on the body and identifying a risk group for which appropriate preventive measures and greater attention to the diagnosis of occupational diseases as part of a planned medical evaluation are required.