Author:
Tassinari da Silva Andressa,Rossi Brabo Gabriela,Dias Marques Isadora,Bajerski Lisiane,Donadel Malesuik Marcelo,Soldateli Paim Clésio
Abstract
Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of bilastine in tablets using 0.1 mol L-1 HCl as solvent. The method was specific, linear, precise, exact and robust at 210 nm, confirming that the method is fast and useful to the routine quality control of bilastine in tablets. The validate method was compared to liquid chromatography (HPLC), which was previously developed and validated to the same drug, and no significative difference between the methods using Student´s t test was found to bilastine quantitation.
Publisher
Universidade Federal do Rio Grande do Sul
Cited by
22 articles.
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