Emergence of Fluconazole-Resistant Sterol 14-Demethylase P450 (CYP51) in Candida albicans Is a Model Demonstrating the Diversification Mechanism of P450-Reference-Cited by-同舟云学术

Emergence of Fluconazole-Resistant Sterol 14-Demethylase P450 (CYP51) in Candida albicans Is a Model Demonstrating the Diversification Mechanism of P450

Published:2000-07 Issue:1 Volume:379 Page:170-171
ISSN:0003-9861
Container-title:Archives of Biochemistry and Biophysics
language:en
Short-container-title:Archives of Biochemistry and Biophysics

Author:

Aoyama Yuri,Kudo Makiko,Asai Kentaro,Okonogi Kenji,Horiuchi Tadao,Gotoh Osamu,Yoshida Yuzo

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference5 articles.

1. Evolution of the P450 gene superfamily:

2. Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

3. Structural and Evolutionary Studies on Sterol 14-Demethylase P450 (CYP51), the Most Conserved P450 Monooxygenase: II. Evolutionary Analysis of Protein and Gene Structures

4. Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

5. Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans

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1. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase;Biochimica et Biophysica Acta (BBA) - General Subjects;2014-06

2. Azole Drugs Trap Cytochrome P450 EryK in Alternative Conformational States,;Biochemistry;2010-10-08

3. Antifungal Drug Resistance;Antifungal Therapy;2009-11-24

4. Effects of Y132H and F145L Substitutions on the Activity, Azole Resistance and Spectral Properties of Candida albicans Sterol 14-Demethylase P450 (CYP51): A Live Example Showing the Selection of Altered P450 through Interaction with Environmental Compounds;The Journal of Biochemistry;2005-05-01

5. Recent progress in the CYP51 research focusing on its unique evolutionary and functional characteristics as a diversozyme P450;Frontiers in Bioscience;2005