Effects of Y132H and F145L Substitutions on the Activity, Azole Resistance and Spectral Properties of Candida albicans Sterol 14-Demethylase P450 (CYP51): A Live Example Showing the Selection of Altered P450 through Interaction with Environmental Compounds

Author:

Kudo Makiko,Ohi Miwa,Aoyama Yuri,Nitahara Yuko,Chung Sung-Kee,Yoshida Yuzo

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,General Medicine

Reference32 articles.

1. Aoyama, Y., Yoshida, Y., and Sato, R. (1984) Yeast cytochrome P-450 catalyzing lanosterol 14α-demethylation, II. Lanosterol metabolism by purified P45014DM and by intact microsomes. J. Biol. Chem.259, 1661–1666

2. Yoshida, Y. (1993) Lanosterol 14α-demethylase (cytochrome P45014DM) in Cytochrome P450 (Schenkman, J.B. and Greim, H., eds.) pp. 627–639, Springer-Verlag, New York

3. Trzaskos, J.M., Bowen, W.D., Shafiee, A., Fischer, R.T., and Gaylor, J.L. (1984) Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. J. Biol. Chem.259, 13402–13412

4. Taton, M. and Rahier, A. (1991) Properties and structural requirements for substrate specificity of cytochrome P-450-dependent obtusifoliol 14α-demethylase from maize (Zea mays) seedlings. Biochem. J.277, 483–492

5. Vanden Bossche, H. (1985) Biochemical targets for antifungal azole derivatives: Hypothesis on the mode of action in Current Topics in Medical Mycology (McGinnis, M.R., ed.) Vol. 1, pp.313–351, Springer-Verlag, New York

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