Decrease in 4-Aminobiphenyl-Induced Methemoglobinemia in Cyp1a2(−/−) Knockout Mice

Author:

Shertzer Howard G.,Dalton Timothy P.,Talaska Glenn,Nebert Daniel W.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference38 articles.

1. Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers;Bryant;Cancer Res.,1987

2. Role of CYP1A2 in caffeine pharmacokinetics and metabolism: Studies using mice deficient in CYP1A2;Buters;Pharmacogenetics,1996

3. Metabolic oxidation of the carcinogens. 4-aminobiphenyl and 4,4′- methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases;Butler;Cancer Res.,1989

4. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines;Butler;Proc. Natl. Acad. Sci. USA,1989

5. A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6;Crespi;Carcinogenesis,1991

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