The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox-Reference-Cited by-同舟云学术

The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox

Published:2018-05-03 Issue:7 Volume:39 Page:851-859
ISSN:0143-3334
Container-title:Carcinogenesis
language:en
Short-container-title:

Author:

Reed Lindsay¹,Arlt Volker M¹²,Phillips David H¹²^ORCID

Affiliation:

1. Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King’s College London, Franklin-Wilkins Building, London, UK

2. NIHR Health Protection Unit in Health Impact of Environmental Health Hazards at King’s College London in Partnership with Public Health England, London, UK

Abstract

Cytochrome P450 enzyme systems have been widely used in vitro to determine the pathways of activation of procarcinogens, but paradoxically, these same enzymes can play a more predominant role in carcinogen detoxification in vivo.

Funder

Medical Research Council

Cancer Research UK

Wellcome Trust

Natural Environment Research Council

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Link

http://academic.oup.com/carcin/article-pdf/39/7/851/26377570/bgy058.pdf

Reference90 articles.