A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA

Author:

SOZOU PETER D.,KIRKWOOD THOMAS B.L.

Publisher

Elsevier BV

Subject

Applied Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modelling and Simulation,General Medicine,Statistics and Probability

Reference26 articles.

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2. From cells to organisms: can we learn about aging from cells in culture?;CAMPISI;Exp. Gerontol.,2001

3. Telomere loss: mitotic clock or genetic time bomb?;HARLEY;Mutat. Res.,1991

4. Statistical Distributions;HASTINGS,1974

5. The limited in vitro lifetime of human diploid cell strains;HAYFLICK;Exp. Cell Res.,1965

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