Common ABCB1 SNP, C3435T could affect systemic exposure of dapagliflozin in healthy subject

Author:

Hwang Jun Gi1ORCID,Jeong Sae Im1ORCID,Kim Yu Kyong1ORCID,Lee Yujin1ORCID,Ji Sang Chun2ORCID,Lee SeungHwan2ORCID,Park Min Kyu1ORCID

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics, Chungbuk National University College of Medicine and Hospital, Cheongju 28644, Korea.

2. Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.

Funder

Chungbuk National University

Publisher

Korean Society for Clinical Pharmacology and Therapeutics

Subject

Pharmacology (medical)

Reference34 articles.

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2. Precision Medicine

3. US Department of Health and Human Services, Food and Drug Administration. Premarket evaluation in early-phase clinical studies and recommendations for labeling. Accessed March 25, 2022. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-pharmacogenomics-premarket-evaluation-early-phase-clinical-studies-and-recommendations/

4. ICH. General principles for planning and design of multi-regional clinical trials E17. The International Council for Harmonisation 2017. Accessed February 9, 2021. https://www.ich.org/page/efficacy-guidelines

5. Commentary on ICH guideline on genomic sampling and data management‐enabling opportunities in drug development and patient treatment

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