Abstract
A review of publications devoted to the analysis of genetic polymorphisms and features of the functioning of genes that affect the pharmacokinetics and pharmacodynamics of sodium-glucose cotransporter-2 inhibitors (SGLT2i) is presented. Objective of the study was to reveal information about genes whose polymorphism may affect the effectiveness of SGLT2i. The review was carried out in accordance with the PRISMA 2020 recommendations, the search for publications was carried out in the PubMed databases (including Medline), Web of Science, as well as Russian scientific electronic libraries eLIBRARY.RU from 1993 to 2022. Polymorphisms in the structure of several genes (SLC5A2, UGT1A9, ABCB1, PNPLA3) have been described that may affect the treatment of type 2 diabetes mellitus complicated by diseases such as chronic heart failure, chronic kidney disease, or non-alcoholic fatty liver disease. The information found on the genetic features of the development of the effects of SGLT2i is limited to a description of the differences in their pharmacokinetics. The relevance of currently available pharmacogenetic studies is largely constrained by small sample sizes.
Subject
General Medicine,Endocrinology, Diabetes and Metabolism,History,Family Practice,General Medicine
Reference27 articles.
1. Pharmacogenetics of new classes of antidiabetic drugs
2. Российская ассоциация эндокринологов. Клинические рекомендации по лечению сахарного диабета 2 типа у взрослых. Режим доступа: https://cr.minzdrav.gov.ru/schema/290_2. Ссылка активна на 30.04.2023 [Rossiiskaia assotsiatsiia endokrinologov. Klinicheskie rekomendatsii po lecheniiu sakharnogo diabeta 2 tipa u vzroslykh. Available at: https://cr.minzdrav.gov.ru/schema/290_2. Accessed: 30.04.2023 (in Russian)].
3. Biology of Human Sodium Glucose Transporters
4. SGLT2 inhibitors and kidneys: mechanisms and main effects in diabetes mellitus patients
5. The pharmacokinetics and pharmacodynamics of SGLT2 inhibitors for type 2 diabetes mellitus: the latest developments