Primary Ovary Choriocarcinoma: Individual DNA Polymorphic Analysis as a Strategy to Confirm Diagnosis and Treatment

Author:

Exman Pedro1,Takahashi Tiago Kenji1,Gattás Gilka F.2,Cantagalli Vanessa Dionisio2,Anton Cristina3,Nalesso Fernando4,Diz Maria Del Pilar Estevez1

Affiliation:

1. Department of Radiology and Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo

2. Department of Legal Medicine, Faculdade de Medicina da Universidade de São Paulo

3. Department of Gynecology and Obstetrics, Instituto do Câncer do Estado de Sâo Paulo, Faculdade de Medicina da Universidade de São Paulo

4. Department of Pathology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Brazil

Abstract

Primary choriocarcinoma of the ovary is rare. Furthermore, this tumor can arise from gestational tissue or pure germ cells of the ovary, with the latter resulting in non-gestational choriocarcinoma. While the clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to assay for the presence of paternal DNA. Accordingly, in the present case, a patient with primary choriocarcinoma of the ovary with a non-gestational origin was confirmed by DNA analysis. The patient subsequently exhibited an excellent response to chemotherapy, and following surgery, achieved complete remission. A pathological analysis of surgical specimens further confirmed the absence of tumor.

Publisher

SAGE Publications

Subject

Oncology,Histology

Reference24 articles.

1. Pure choriocarcinoma of the ovary: a case report

2. Optimisation of DNA and RNA extraction from archival formalin-fixed tissue

3. An alternative protocol for DNA extraction from formalin fixed and paraffin wax embedded tissue

4. National Institutes of Health. National Cancer Institute. Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events, v4.0. Available from: http://ctep.cancer.gov/forms/CTCAEv4.pdf.

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