Vasodilator Effect of Extract Prepared from Uncariae Ramulus on Isolated Rat Aorta-Reference-Cited by-同舟云学术

Vasodilator Effect of Extract Prepared from Uncariae Ramulus on Isolated Rat Aorta

Published:2000-01 Issue:02 Volume:28 Page:197-203
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Goto Hirozo¹,Sakakibara Iwao²,Shimada Yutaka¹,Kasahara Yuji¹,Terasawa Katsutoshi¹

Affiliation:

1. Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan

2. Tsumura Central Research Laboratories, Tsumura & Co., 3586, Yoshiwara Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan

Abstract

Uncariae ramulus et Uncus (URE) has a vasodilator effect. Its mechanism consists of not only endothelium-independent relaxation with Ca 2+ channel blocking effect but also endothelium-dependent relaxation with nitric oxide. The active components are alkaloids and tannin contained in Uncariae ramulus et Uncus. They also show a superoxide dismutase-like effect and suppressed vasocontraction induced by xanthine and xanthine oxidase. These mechanisms may also influence vasodilatation by Uncariae ramulus et Uncus in vivo.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X00000246

Reference10 articles.

1. Hypotensive Action of 3α-Dihydrocadambine, An Indole Alkaloid Glycoside ofUncaria Hooks

2. Effect of Uncariae Ramulus et Uncus on Endothelium in Spontaneously Hypertensive Rats

3. Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats

4. Structure-activity relationship of yohimbine and its related analogs in blocking alpha-1 and alpha-2 adrenoceptors: A comparative study of cardiovascular activities.

5. The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy;Frontiers in Pharmacology;2021-04-01

2. Aqueous extract of Lespedeza cuneata improves male menopause by increase of nitric oxide and dihydrotestosterone;Food Science and Biotechnology;2018-07-11

3. A Case of Refractory Transient Ischemic Attack Successfully Managed with Chotosan;Kampo Medicine;2017

4. Anti-Neuroinflammatory Effects of Uncaria sinensis in LPS-Stimulated BV2 Microglia Cells and Focal Cerebral Ischemic Mice;The American Journal of Chinese Medicine;2015-01

5. Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice;Journal of Ethnopharmacology;2011-12