The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay-Reference-Cited by-同舟云学术

The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay

Published:1985-06 Issue:6 Volume:37 Page:401-404
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Kanatani Hirotoshi¹,Kohda Hiroshi¹,Yamasaki Kazuo¹,Hotta Izumi²,Nakata Yoshihiro²,Segawa Tomio²,Yamanaka Etsuji³,Aimi Norio³,Sakai Shin'ichiro³

Affiliation:

1. Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima 734, Japan

2. Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima 734, Japan

3. Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 260, Japan

Abstract

Abstract Of the alkaloids obtained from Uncaria sinensis Oliv., geissoschizine methyl ether, corynantheine and dihydrocorynantheine decreased specific [3H]5-HT binding to membrane preparations from rat brain and from in-vitro experiments on guinea-pig ileum, these alkaloids were found to be partial agonists for 5-HT receptors. Therefore, they might be useful in the treatment of diseases resulting from disorders of 5-HT metabolism.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/6/401/37526825/j.2042-7158.1985.tb03023.x.pdf

Reference9 articles.

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2. Studies of Plants containing Indole Alkaloids. (2). On the Alkaloids of Uncaria rhynchophylla MIQ

3. Ganglion Blocking Effect of Indole Alkaloids contained in Uncaria Genus and Amsonia Genus and Related Synthetic Compounds on the Rat Superior Cervical Ganglion in Situ

4. Effect of indole alkaloids from Gardneriagenus and Uncaria genus on neuromuscular transmission in the rat limb in situ.

5. The mode of action of nicotine and curari, determined by the form of the contraction curve and the method of temperature coefficients

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