Graphene-based stochastic sensors for pattern recognition of gastric cancer biomarkers in biological fluids-Reference-Cited by-同舟云学术

Graphene-based stochastic sensors for pattern recognition of gastric cancer biomarkers in biological fluids

Published:2019-12 Issue:11n12 Volume:23 Page:1365-1370
ISSN:1088-4246
Container-title:Journal of Porphyrins and Phthalocyanines
language:en
Short-container-title:J. Porphyrins Phthalocyanines

Author:

Stefan-van Staden Raluca-Ioana¹²,Ilie-Mihai Ruxandra-Maria¹²,Pogacean Florina³,Pruneanu Stela³

Affiliation:

1. Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021, Bucharest-6, Romania

2. Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 060042, Bucharest, Romania

3. National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, RO-400293, Cluj-Napoca, Romania

Abstract

This paper proposes pattern recognition of gastric cancer biomarkers CEA, CA19-9 and p53 in whole blood and urine samples using a stochastic sensor based on exfoliated graphene (E-NGr) paste modified with protoporphyrin IX. The proposed sensor covered large ranges of concentrations: 1 × 10[Formula: see text]–1 × 10[Formula: see text]g/mL for CEA, 1 × 10[Formula: see text]–1 × 102 U/mL for CA19-9, and 0.2–5.0 [Formula: see text]g/mL for p53. These ranges allowed the determination of the three biomarkers from early to latest stages of gastric cancer. Validation of the pattern recognition of gastric cancer biomarkers was accomplished using biological samples: whole blood and urine.

Funder

Romanian National Authority for Scientific Research, CNCS-UEFISCDI

Research Center and Advanced Technologies for Alternative Energies CETATEA

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1088424619501293

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2. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES