Evaluation of Magnetic Hyperthermia Efficiency of PEG-Coated Fe3O4 Nanoparticles

Author:

Srivastava Neha1ORCID,Baranwal Manoj1ORCID,Chudasama Bhupendra23ORCID

Affiliation:

1. Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India

2. School of Physics and Materials Science, Thapar Institute of Engineering and Technology, Patiala 147004, India

3. TIET-VT Center of Excellence in Emerging Materials, Thapar Institute of Engineering and Technology, Patiala 147004, India

Abstract

Magnetic nanoparticle hyperthermia has drawn considerable interest in cancer therapy. In this study, we report the synthesis of PEG-coated Fe3O4 nanoparticles and evaluate their suitability for magnetic hyperthermia applications. Fe3O4 nanoparticles were synthesized by the chemical coprecipitation method, which are coated with polyethylene glycol (PEG). PEG-coated Fe3O4 nanoparticles were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), dynamic light scattering (DLS) and transmission electron microscopy (TEM). Synthesized nanoparticles possess inverse-spinel structural with a crystallite size of 9.1[Formula: see text]nm. From the M-H hysteresis loops, it was confirmed that the synthesized Fe3O4 nanoparticles were superparamagnetic. The physical size of bare Fe3O4 nanoparticles, as determined from the HR-TEM, is [Formula: see text][Formula: see text]nm, and the corresponding hydrodynamic size of PEG-coated Fe3O4 nanoparticles is [Formula: see text][Formula: see text]nm. Magnetic hyperthermia efficiency of PEG-coated Fe3O4 nanoparticles was determined as a function of magnetic field frequency (162–935.6[Formula: see text]kHz), field strength (5–12[Formula: see text]mT) and nanoparticle concentration (1–100[Formula: see text]mg/mL). Temperature rise in an aqueous dispersion of PEG-coated Fe3O4 nanoparticles was measured for 20[Formula: see text]min. The specific loss power (SLP) was calculated by the corrected slope method. SLP values of PEG-coated Fe3O4 nanoparticles increase with magnetic field frequency and field strength and decrease with nanoparticle concentration. The optimum hyperthermia performance of PEG-coated Fe3O4 nanoparticles was observed for 935.6[Formula: see text]kHz frequency, 10[Formula: see text]mT field strength and 25[Formula: see text]mg/mL concentration. Under these conditions, the measured SLP of PEG-coated Fe3O4 nanoparticles was 4.43[Formula: see text]W/g. These results show that the synthesized PEG-coated Fe3O4 nanoparticles could be a potential candidate for magnetic hyperthermia treatment of cancer.

Funder

DST-FIST

Centre of Excellence in Emerging Materials

Publisher

World Scientific Pub Co Pte Ltd

Subject

Condensed Matter Physics,General Materials Science

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