Controlled Release Electrochemical Synthesis and Cytotoxicity Study of Copper(II) Nanoparticles in Copper(II) Decanoate Complex

Abstract

In the present study, a controlled release electrochemical (CRE) technique based on the controlled release of Cu[Formula: see text] ion from Cu anode in the presence of decanoic acid (HDe) has been used to synthesize Cu(II) decanoate (CuDe2) complex. The effect of applied voltages (1–10[Formula: see text]V) and electrolyte concentrations (0.1–2.0[Formula: see text]M CH3COONH4) during the electrolysis on the nanoparticles obtained was studied using TEM. The results reveal that small-sized nanoparticles ([Formula: see text][Formula: see text]nm) were obtained by using lowest applied voltage and CH3COONH4 concentration (1[Formula: see text]V and 0.1[Formula: see text]M, respectively). The smallest nanoparticle obtained was then used in the cytotoxicity study against A549 and HeLa cells. The synthesized complex gives moderate cytotoxic effect on the selected cells (IC[Formula: see text]M and 20.89[Formula: see text][Formula: see text]M, respectively) and low cytotoxic effect on normal cells (IMR90). Apoptosis is the mode of cell death based on the apoptosis assay that has been conducted.