New Cu(II)-bearing coordination polymer: Crystal structure, molecular docking, and protective activity on coronary heart disease by reducing ROS production

Abstract

A novel chain-like coordination polymer [CuLCl2(DMF)]n (1) with helical double chains was synthesized using flexible bis(pyridylurea) ligand 1,1[Formula: see text]-[oxybis(2,1-phenylene)] bis(3-pyridin-3-ylurea) (L) under solvothermal conditions and characterized by single-crystal X-ray diffraction and elemental analysis. A green grinding processing method was used to produce the required complex 1 nanorods, which featured good water dispersibility. The protective effect of the compound was evaluated in vivo, following the construction of the coronary heart disease (CHD) rat model and nano 1 treatment. The cardiac function promoted by nano 1 was measured using the left ventricular systolic diameter (LVID) and left ventricular ejection fraction (LVEF). The anti-oxidative activity of nano 1 was determined with an ROS detection kit. In addition, the interaction between the Cu(II) complex with protein NF-[Formula: see text]B was examined by molecular docking.