Affiliation:
1. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China
Abstract
Catalysis-based chemodynamic therapy (CDT) is an emerging cancer treatment strategy which uses a Fenton-like reaction to kill tumor cells by catalyzing endogenous hydrogen peroxide (H2O[Formula: see text] into a toxic hydroxyl radical ([Formula: see text]OH). The performance of CDT is greatly dependent on PDT agent. Herein, mitochondria-targeting Pt nanoclusters were synthesized using cytochrome c aptamer (CytcApt) as template. The obtained CytcApt-PtNCs can produce [Formula: see text]OH by H2O2 under the acidic conditions. Moreover, CytcApt-PtNCs could kill 4T1 tumor cells in a pH-dependent manner, but had no side effect on normal 293T cells. Therefore, CytcApt-PtNCs possess excellent therapeutic effect and good biosafety, indicating their great potential for CDT.
Funder
the Cross Research Fund of Biomedical Engineering of Shanghai Jiao Tong University
Publisher
World Scientific Pub Co Pte Lt
Subject
Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献