Stabilities of Irradiated DNA Complexes from Sarcoma 45 Tumors with Mitoxantrone at Small Fillings-Reference-Cited by-同舟云学术

Stabilities of Irradiated DNA Complexes from Sarcoma 45 Tumors with Mitoxantrone at Small Fillings

Published:2016-12 Issue:04 Volume:11 Page:139-147
ISSN:1793-0480
Container-title:Biophysical Reviews and Letters
language:en
Short-container-title:Biophys. Rev. Lett.

Author:

Hakobyan Sergey N.¹,Shahinyan Mariam A.²,Babayan Yuri S.³

Affiliation:

1. Department of Mechanical Engineering, State Engineering University of Armenia, 105 Teryan St., Yerevan 0009, Armenia

2. Department of Biophysics, Faculty of Biology, Yerevan State University, 1 Alex Manoogian St. Yerevan 0025, Armenia

3. Department of Physics and Electrochemicals, National University of Architecture and Construction of Armenia, 105 Teryan St., Yerevan 0009, Armenia

Abstract

In the present work, the thermostabilities of mitoxantrone (MTX) complexes with DNA from sarcoma 45 and healthy rat liver were studied. DNAs from both sources were irradiated by resonant (64.5 GHz and 50.3 GHz) and nonresonant (48.3 GHz) frequencies of water. The obtained data showed that DNA solution irradiation by resonant frequencies of water induces a dehydration of nucleotides and Na[Formula: see text] ions in the solution. It is shown that at relatively low concentrations of MTX, when one MTX molecule binds to almost 100 pairs of bases of DNA, the thermostabilities of complexes decrease. Moreover, this change is more pronounced ([Formula: see text]C) at the complex formation with DNA released from sarcoma 45 tumor.

Publisher

World Scientific Pub Co Pte Lt

Subject

Molecular Biology,Structural Biology,Biophysics

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793048016500028

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