Interaction of Antitumor Agent Mitoxantrone with Double Helical Synthetic Polyribonucleotides Poly(G)⋅Poly(C) and Poly(I)⋅Poly(C)-Reference-Cited by-同舟云学术

Interaction of Antitumor Agent Mitoxantrone with Double Helical Synthetic Polyribonucleotides Poly(G)⋅Poly(C) and Poly(I)⋅Poly(C)

Published:2017-12 Issue:04 Volume:12 Page:165-176
ISSN:1793-0480
Container-title:Biophysical Reviews and Letters
language:en
Short-container-title:Biophys. Rev. Lett.

Author:

Babayan Yuri S.¹,Hakobyan Sergey N.²,Ghazaryan Rusanna S.³,Shahinyan Mariam A.⁴

Affiliation:

1. Department of Physics and Electrotechnics, National University of Architecture and Construction of Armenia, 105 Teryan, Yerevan 0009, Armenia

2. Department of Mechanical Engineering, State Engineering University of Armenia, Teryan St. 105, Yerevan 0009, Armenia

3. Department of Molecular Physics, Faculty of Physics, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia

4. Department of Biophysics, Faculty of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia

Abstract

The interaction of antitumor drug mitoxantrone (MTX) with double-stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-Visible absorption, circular dichroism) techniques. The results show a base specificity in this interaction: the association constant with poly(G)[Formula: see text]poly(C) is higher than with poly(I)[Formula: see text]poly(C).Values of changes of the system enthalpy and entropy due to complex-formation were determined through the temperature dependence of the binding constant. Calculations show that due to the intercalation interaction of MTX, the values of changes of the system entropy and enthalpy differ from those obtained at ehtidium bromide interaction with synthetic polyribonucleotides, which shows that the intercalation interaction of MTX with double-stranded RNA significantly differs from that of ethidium bromide with RNA.

Publisher

World Scientific Pub Co Pte Lt

Subject

Molecular Biology,Structural Biology,Biophysics

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793048017500096

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