Stain-less staining for computed histopathology-Reference-Cited by-同舟云学术

Stain-less staining for computed histopathology

Published:2015-03 Issue:01 Volume:03 Page:27-31
ISSN:2339-5478
Container-title:TECHNOLOGY
language:en
Short-container-title:Technology

Author:

Mayerich David¹,Walsh Michael J.¹²,Kadjacsy-Balla Andre³,Ray Partha S.⁴,Hewitt Stephen M.⁵,Bhargava Rohit¹²⁶

Affiliation:

1. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

2. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 and Carle Foundation Hospital, Urbana, IL 61801, USA

3. Department of Pathology and University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA

4. Carle Cancer Center, Carle Foundation Hospital, Urbana, IL and Department of Surgery, and University of Illinois Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

5. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

6. Departments of Mechanical Science and Engineering, Electrical and Computer Engineering, Chemical and Biomolecular Engineering and Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

Abstract

Dyes such as hematoxylin and eosin (H&E) and immunohistochemical stains have been increasingly used to visualize tissue composition in research and clinical practice. We present an alternative approach to obtain the same information using stain-free chemical imaging. Relying on Fourier transform infrared (FT-IR) spectroscopic imaging and computation, stainless computed histopathology can enable a rapid, digital, quantitative and non-perturbing visualization of morphology and multiple molecular epitopes simultaneously in a variety of research and clinical pathology applications.

Publisher

World Scientific Pub Co Pte Lt

Link

https://www.worldscientific.com/doi/pdf/10.1142/S2339547815200010

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