Permanent proteins in the urine of healthy humans during the Mars-500 experiment-Reference-Cited by-同舟云学术

Permanent proteins in the urine of healthy humans during the Mars-500 experiment

Published:2015-02 Issue:01 Volume:13 Page:1540001
ISSN:0219-7200
Container-title:Journal of Bioinformatics and Computational Biology
language:en
Short-container-title:J. Bioinform. Comput. Biol.

Author:

Larina Irina M.¹²,Pastushkova Lyudmila Kh.¹²,Tiys Evgeny S.³,Kireev Kirill S.¹⁴,Kononikhin Alexey S.⁵⁶,Starodubtseva Natalia L.⁷,Popov Igor A.⁸⁵⁶,Custaud Marc-Antoine²⁹,Dobrokhotov Igor V.¹²,Nikolaev Evgeny N.⁸⁵⁶¹⁰,Kolchanov Nikolay A.³,Ivanisenko Vladimir A.³

Affiliation:

1. Institute for Biomedical Problems — Russian Federation State, Scientific Research Center Russian Academy of Sciences, Moscow 123007, Russia

2. CaDyWEC International Laboratory, Angers Faculty of Medicine, 49045 Angers Cedex 01, France

3. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia

4. Gagarin Cosmonauts Training Center, Star City, Moscow Region 141160, Russia

5. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow 117829, Russia

6. Moscow Institute of Physics and Technology, Moscow 141700, Russia

7. Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

8. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow 119334, Russia

9. University of Angers, Angers 49000, France

10. Skolkovo Institute of Science and Technology, Novaya St., 100, Skolkovo 143025, Russian Federation

Abstract

Urinary proteins serve as indicators of various conditions in human normal physiology and disease pathology. Using mass spectrometry proteome analysis, the permanent constituent of the urine was examined in the Mars-500 experiment (520 days isolation of healthy volunteers in a terrestrial complex with an autonomous life support system). Seven permanent proteins with predominant distribution in the liver and blood plasma as well as extracellular localization were identified. Analysis of the overrepresentation of the molecular functions and biological processes based on Gene Ontology revealed that the functional association among these proteins was low. The results showed that the identified proteins may be independent markers of the various conditions and processes in healthy humans and that they can be used as standards in determination of the concentration of other proteins in the urine.

Publisher

World Scientific Pub Co Pte Lt

Subject

Computer Science Applications,Molecular Biology,Biochemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0219720015400016

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