Some Heterocyclic Hydrazone Compounds: Synthesis, Spectral Characterization and Anticancer Activity Study

Abstract

Cancer is currently ongoing to be a significant health problem threatening human health. Hydrazone compounds constitute a popular class of organic compounds used in novel drug discovery studies in therapy of cancer. In the current study, the preparation and structural characterization of some heterocyclic hydrazone compounds (7-12) and their anticancer capacities against HeLa cervical cancer and MCF-7 breast cancer cell lines were reported. The target compounds were characterized by some spectroscopic techniques (1H NMR, 13C NMR and FT-IR). The in vitro cytotoxic potentials of the target molecules were assessed by using MTT assay against two cancer cell lines. L929 mouse fibroblast cell lines were employed as normal cell. The results displayed that some of the tested molecules had varying anticancer activities. Among the tested compounds, compound 8 indicated anticancer activity against HeLa cells with IC50 value of 34.38 µM. On the other hand, of these tested compounds, compound 11 (IC50 = 26.84 µM) displayed anticancer activity against MCF-7 cells.