Affiliation:
1. BATMAN ÜNİVERSİTESİ/TEKNİK BİLİMLER MESLEK YÜKSEKOKULU/KİMYA VE KİMYASAL İŞLEME TEKNOLOJİLERİ BÖLÜMÜ
2. BATMAN ÜNİVERSİTESİ
3. AYDIN ADNAN MENDERES ÜNİVERSİTESİ
Abstract
Cancer is currently ongoing to be a significant health problem threatening human health. Hydrazone compounds constitute a popular class of organic compounds used in novel drug discovery studies in therapy of cancer. In the current study, the preparation and structural characterization of some heterocyclic hydrazone compounds (7-12) and their anticancer capacities against HeLa cervical cancer and MCF-7 breast cancer cell lines were reported. The target compounds were characterized by some spectroscopic techniques (1H NMR, 13C NMR and FT-IR). The in vitro cytotoxic potentials of the target molecules were assessed by using MTT assay against two cancer cell lines. L929 mouse fibroblast cell lines were employed as normal cell. The results displayed that some of the tested molecules had varying anticancer activities. Among the tested compounds, compound 8 indicated anticancer activity against HeLa cells with IC50 value of 34.38 µM. On the other hand, of these tested compounds, compound 11 (IC50 = 26.84 µM) displayed anticancer activity against MCF-7 cells.
Cited by
3 articles.
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1. Design, spectroscopic characterization,
in silico
and
in vitro
cytotoxic activity assessment of newly synthesized thymol Schiff base derivatives;Journal of Biomolecular Structure and Dynamics;2024-01-10
2. Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base ligand;Journal of Molecular Structure;2023-11
3. Flavothione‐3‐carboxylate Derivatives: Synthesis, Molecular Docking, and Antiproliferative Activity against Breast Cancer;ChemistrySelect;2023-09-19